DIET AND GUT MICROBIOME: THE ROLE OF PREBIOTICS AND PROBIOTICS IN HUMAN HEALTH
DOI:
https://doi.org/10.63330/aurumpub.036-015Keywords:
Gut, Fatty acids, Intestinal homeostasisAbstract
Scientific evidence has accumulated over the past few years demonstrating that diet plays a determining role in human quality of life, mainly through modulating the gut microbiome and its interaction with the external environment. Dietary strategies based on the consumption of prebiotic and probiotic foods have been associated with improved gut health, maintenance of intestinal barrier integrity, and modulation of metabolic and immunological responses. These effects are related, among other mechanisms, to the production of short-chain fatty acids, essential metabolites for maintaining intestinal balance. In this context, this review explores the role of foods as intervention measures in modulating the gut microbiome and contributing to intestinal barrier integrity.
Downloads
References
AFZAAL, M. et al. Human gut microbiota in health and disease: unveiling the relationship. Frontiers in Microbiology, v. 13, 2022. DOI: 10.3389/fmicb.2022.999001.
ARONIADIS, Olga C.; GRINSPAN, Ari. The Gut Microbiome: A Primer for the Clinician. The American Journal of Gastroenterology, v. 119, n. 1S, p. S2-S6, jan. 2024. DOI: https://doi.org/10.14309/ajg.0000000000002583
BEAM, A.; CLINGER, E.; HAO, L. Effect of diet and dietary components on the composition of the gut microbiota. Nutrients, v. 13, n. 8, 2021. DOI: 10.3390/nu13082795.
BOKULICH, N. A. et al. Antibiotics, birth mode, and diet shape microbiome maturation during early life. Science Translational Medicine, v. 8, n. 343, p. 343ra82, 15 jun. 2016. DOI: https://doi.org/10.1126/scitranslmed.aad7121
TARRACCHINI, C et al. Vitamin biosynthesis in the gut: interplay between mammalian host and its resident microbiota. Microbiology and Molecular Biology Reviews, v. 89, n. 2, e00184-23, 2025. DOI: 10.1128/mmbr.00184-23.
DI VINCENZO, F.; DEL GAUDIO, A.; PETITO, V.; LOPETUSO, L. R.; SCALDAFERRI, F. Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review. Internal and Emergency Medicine, v. 19, n. 2, p. 275–293, 2024. DOI: 10.1007/s11739-023-03374-w.
DING, Z. et al. Disease-driven restructuring of the gut microbiome underlies inflammatory bowel disease dysbiosis. Frontiers in Microbiology, v. 16, 2026. DOI: 10.3389/fmicb.2025.1744574.
FASSARELLA, M.; BLAAK, E. E.; PENDERS, J.; NAUTA, A.; SMIDT, H.; ZOETENDAL, E. G. Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health. Gut, v. 70, n. 3, p. 595–605, 2021. DOI: 10.1136/gutjnl-2020-321747.
GU, J. et al. Metagenomic insights into the effects of fructooligosaccharides (FOS) on the composition of luminal and mucosal microbiota in C57BL/6J mice, especially the Bifidobacterium composition. Nutrients, v. 11, n. 10, 2019. DOI: 10.3390/nu11102431.
HERTLI, S.; ZIMMERMANN, P. Molecular interactions between the intestinal microbiota and the host. Molecular Microbiology, v. 117, n. 6, p. 1297-1307, jun. 2022. DOI: https://doi.org/10.1111/mmi.14905
GUO, M.; LI, J.; ZHANG, L.; CHEN, C.; WEI, Y.; SHEN, Z. A. Effects of oral supplementation of probiotics on body weight and visceral fat in obese patients: a meta-analysis and systematic review. Scientific Reports, v. 15, n. 1, 2025. DOI: 10.1038/s41598-025-90820-8.
KOK, C. R.; ROSE, D. J.; CUI, J.; WHISENHUNT, L.; HUTKINS, R. Identification of carbohydrate gene clusters obtained from in vitro fermentations as predictive biomarkers of prebiotic responses. BMC Microbiology, v. 24, n. 1, 2024. DOI: 10.1186/s12866-024-03344-y.
KARIM, M. R. et al. Butyrate’s microbial synthesis, absorption, and preventive roles against colorectal and lung cancer. Archives of Microbiology, 2024. DOI: 10.1007/s00203-024-03834-7.
PERLER, B. K.; FRIEDMAN, E. S.; WU, G. D. The role of the gut microbiota in the relationship between diet and human health. Annual Review of Physiology, 2026. DOI: 10.1146/annurev-physiol-031522.
POPOVIĆ, N.; BRDARIĆ, E.; ÐOKIĆ, J.; DINIĆ, M.; VELJOVIĆ, K.; GOLIĆ, N.; TERZIĆ-VIDOJEVIĆ, A. Yogurt produced by novel natural starter cultures improves gut epithelial barrier in vitro. Microorganisms, v. 8, n. 10, p. 1–18, 2020. DOI: 10.3390/microorganisms8101586.
RAMASINGHE, C.; BORDIGA, M.; XU, B. A comprehensive review of the triangular relationship among diet, gut microbiota, and aging. International Journal of Molecular Sciences, v. 26, n. 18, p. 8785, 9 set. 2025. DOI: https://doi.org/10.3390/ijms26188785
RONDINELLA, D. et al. The detrimental impact of ultra-processed foods on the human gut microbiome and gut barrier. Nutrients, v. 17, n. 5, 2025. DOI: 10.3390/nu17050859.
ROSS, F. C. et al. The interplay between diet and the gut microbiome: implications for health and disease. Nature Reviews Microbiology, v. 22, n. 11, p. 671–686, 2024. DOI: 10.1038/s41579-024-01068-4.
ROY, S.; DHANESHWAR, S. Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: current perspectives. World Journal of Gastroenterology, v. 29, n. 14, p. 2078–2100, 2023. DOI: 10.3748/WJG.V29.I14.2078.
SAVAIANO, D. A. Lactose digestion from yogurt: mechanism and relevance. American Journal of Clinical Nutrition, v. 99, n. 5, 2014. DOI: 10.3945/ajcn.113.073023.
UPADHYAY, P. et al. Gut microbiota and dietary strategies for age-related diseases. Molecular Nutrition & Food Research, v. 69, n. 24, p. e70308, dez. 2025. DOI: https://doi.org/10.1002/mnfr.70308
WAITZBERG, D. et al. Can the evidence-based use of probiotics (notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) mitigate the clinical effects of antibiotic-associated dysbiosis? Advances in Therapy, v. 41, n. 3, p. 901–914, 2024. DOI: 10.1007/s12325-024-02783-3.
WANG, Q. et al. Interaction between gut microbiota and immunity in health and intestinal disease. Frontiers in Immunology, v. 16, 2025. DOI: 10.3389/fimmu.2025.1673852.
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.