OS PADRÕES ALIMENTARES COMO INTERVENÇÃO NO ESTRESSE OXIDATIVO E NA INFLAMAÇÃO
DOI:
https://doi.org/10.63330/aurumpub.042-001Palavras-chave:
Dieta, Alimentos bioativos, Estresse oxidativoResumo
O estresse oxidativo e a inflamação crônica, desempenham papel central na fisiopatologia de diversas doenças crônicas. Nesse contexto, compostos bioativos de origem alimentar têm sido amplamente investigados por sua capacidade de modular vias inflamatórias e redox. A literatura indica que compostos como curcumina, gingeróis e substâncias sulfuradas do alho e tomates, modulando fatores de transcrição inflamatórios e ativando sistemas antioxidantes endógenos. No entanto, os efeitos observados em humanos apresentam heterogeneidade, influenciada por fatores como forma de elaboração, dose, matriz alimentar e variabilidade do paciente. Os padrões alimentares ricos em alimentos de origem vegetal, contendo múltiplos compostos bioativos, estão associados à melhora de marcadores relacionados ao estresse oxidativo e à inflamação. Considerando a complexidade da matriz alimentar e dos sistemas biológicos humanos, os resultados reforçam a importância de abordagem dietética individualizada, em detrimento da suplementação isolada de compostos específicos, especialmente diante da ausência de padronização de doses eficazes.
Downloads
Referências
AL-MADHAGI, H.; MASOUD, A. Limitations and challenges of antioxidant therapy. Phytotherapy Research, v. 38, n. 12, p. 5549–5566, 2024. DOI: https://doi.org/10.1002/ptr.8335.
ANAND, P.; KUNNUMAKKARA, A. B.; NEWMAN, R. A.; AGGARWAL, B. B. Bioavailability of curcumin: problems and promises. Molecular Pharmaceutics, v. 4, n. 6, p. 807–818, 2007. DOI: https://doi.org/10.1021/mp700113r.
AVERILL-BATES, D. Reactive oxygen species and cell signaling. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, v. 1871, n. 2, p. 119573, 2024. DOI: https://doi.org/10.1016/j.bbamcr.2023.119573.
BISCHOFF-KONT, I.; FÜRST, R. Benefits of ginger and its constituent 6-shogaol in inhibiting inflammatory processes. Pharmaceuticals, v. 14, n. 6, 2021. DOI: https://doi.org/10.3390/ph14060571.
CAS, M. D.; GHIDONI, R. Dietary curcumin: correlation between bioavailability and health potential. Nutrients, v. 11, n. 9, 2019. DOI: https://doi.org/10.3390/nu11092147.
EDWARDS, R. L.; LUIS, P. B.; VARUZZA, P. V.; et al. The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites. Journal of Biological Chemistry, v. 292, n. 52, p. 21243–21252, 2017. DOI: https://doi.org/10.1074/jbc.RA117.000123.
EMRAN, T. B. Neuroprotective potential of epigallocatechin gallate in neurodegenerative diseases: insights into molecular mechanisms and clinical relevance. Brain Research, v. 1860, p. 149693, 2025. DOI: https://doi.org/10.1016/j.brainres.2025.149693.
FAGIANI, F.; CATANZARO, M.; BUOSO, E.; et al. Targeting cytokine release through the differential modulation of Nrf2 and NF-κB pathways by electrophilic/non-electrophilic compounds. Frontiers in Pharmacology, v. 11, 2020. DOI: https://doi.org/10.3389/fphar.2020.01256.
GADINA, M.; GAZANIGA, N.; VIAN, L.; FURUMOTO, Y. Small molecules to the rescue: inhibition of cytokine signaling in immune-mediated diseases. Journal of Autoimmunity, v. 85, p. 20–31, 2017. DOI: https://doi.org/10.1016/j.jaut.2017.06.006.
GARCIA, C.; BLESSO, C. N. Antioxidant properties of anthocyanins and their mechanism of action in atherosclerosis. Free Radical Biology and Medicine, v. 172, p. 152–166, 2021b. DOI: https://doi.org/10.1016/j.freeradbiomed.2021.05.040.
GONZÁLEZ, P.; LOZANO, P.; ROS, G.; SOLANO, F. Hyperglycemia and oxidative stress: an integral, updated and critical overview of their metabolic interconnections. International Journal of Molecular Sciences, v. 24, n. 11, 2023a. DOI: https://doi.org/10.3390/ijms24119352.
GUAN, R.; VAN LE, Q.; YANG, H.; et al. A review of dietary phytochemicals and their relation to oxidative stress and human diseases. Chemosphere, v. 271, p. 129499, 2021. DOI: https://doi.org/10.1016/j.chemosphere.2020.129499.
LEE, H,.; KAY, C.; ABDELHAMID, A.; et al. Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. The American Journal of Clinical Nutrition, v. 95, n. 3, p. 740–751, 2012. DOI: https://doi.org/10.3945/ajcn.111.023457.
ISLAM, M. R.; RAUF, A.; AKTER, S.; et al. Epigallocatechin 3-gallate-induced neuroprotection in neurodegenerative diseases: molecular mechanisms and clinical insights. Molecular and Cellular Biochemistry, v. 480, n. 6, p. 3363–3383, 2025. DOI: https://doi.org/10.1007/s11010-025-05211-4.
JOMOVA, K.; RAPTOVA, R.; ALOMAR, S. Y.; et al. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Archives of Toxicology, v. 97, n. 10, p. 2499–2574, 2023a. DOI: https://doi.org/10.1007/s00204-023-03562-9.
LIU, H.; JIAO, Y.; WANG, P. C.; et al. Oxidative stress and antioxidant therapeutic mechanisms. Pharmacology & Therapeutics, v. 278, p. 108962, 2026. DOI: https://doi.org/10.1016/j.pharmthera.2025.108962.
LÓPEZ-SOLÍS, R.; CASTRO-BARQUERO, S.; DONAT-VARGAS, C.; et al. Lycopene intake and prostate cancer risk in men at high cardiovascular risk: a prospective cohort study. BMC Medicine, v. 23, n. 1, 2025. DOI: https://doi.org/10.1186/s12916-025-04440-0
LUGRIN, J.; ROSENBLATT-VELIN, N.; PARAPANOV, R.; LIAUDET, L. The role of oxidative stress during inflammatory processes. Biological Chemistry, v. 395, n. 2, p. 203–230, 2014b. DOI: https://doi.org/10.1515/hsz-2013-0241.
ALLEN, L. H. Micronutrients assessment, requirements, deficiencies, and interventions. The New England Journal of Medicine, 2025. Disponível em: https://www.nejm.org. Acesso em: [dia mês ano].
MOHAMMADI, N.; FARRELL, M.; O’SULLIVAN, L.; et al. Effectiveness of anthocyanin-containing foods and nutraceuticals in mitigating oxidative stress, inflammation, and cardiovascular health-related biomarkers: a systematic review of animal and human interventions. Food & Function, v. 15, n. 7, p. 3274–3299, 2024. DOI: https://doi.org/10.1039/d3fo04579j
MORVARIDZADEH, M.; FAZELIAN, S.; AGAH, S.; et al. Effect of ginger (Zingiber officinale) on inflammatory markers: a systematic review and meta-analysis of randomized controlled trials. Cytokine, v. 135, p. 155224, 2020. DOI: https://doi.org/10.1016/j.cyto.2020.155224.
MOTA, J. C.; ALMEIDA, P. P.; FREITAS, M. Q.; et al. Far from being a simple question: the complexity between in vitro and in vivo responses from nutrients and bioactive compounds with antioxidant potential. Food Chemistry, v. 402, p. 134351, 2023. DOI: https://doi.org/10.1016/j.foodchem.2022.134351.
NAKADATE, K.; ITO, N.; KAWAKAMI, K.; YAMAZAKI, N. Anti-inflammatory actions of plant-derived compounds and prevention of chronic diseases: from molecular mechanisms to applications. International Journal of Molecular Sciences, v. 26, n. 11, 2025. DOI: https://doi.org/10.3390/ijms26115206.
OZKAN, G.; GÜNAL-KÖROĞLU, D.; KARADAG, A.; et al. A mechanistic updated overview on lycopene as potential anticancer agent. Biomedicine & Pharmacotherapy, v. 161, p. 114428, 2023. DOI: https://doi.org/10.1016/j.biopha.2023.114428.
PAUDEL, K. R.; ORENT, J.; PENELA, O. G. Pharmacological properties of ginger (Zingiber officinale): what do meta-analyses say? a systematic review. Frontiers in Pharmacology, v. 16, 2025. DOI: https://doi.org/10.3389/fphar.2025.1619655.
RAUTIAINEN, S.; SESSO, H. D.; MANSON, J. A. E. Large-scale randomized clinical trials of bioactives and nutrients in relation to human health and disease prevention: lessons from the VITAL and COSMOS trials. Molecular Aspects of Medicine, v. 61, p. 12–17, 2018. DOI: https://doi.org/10.1016/j.mam.2017.12.001.
RODRIGUEZ-MATEOS, A.; WEBER, T.; SKENE, S. S.; et al. Assessing the respective contributions of dietary flavanol monomers and procyanidins in mediating cardiovascular effects in humans: randomized, controlled, double-masked intervention trial. The American Journal of Clinical Nutrition, v. 108, n. 6, p. 1229–1237, 2018. DOI: https://doi.org/10.1093/ajcn/nqy229.
ROŞIAN, Ş. H.; BOARESCU, I.; BOARESCU, P. M. Antioxidant and anti-inflammatory effects of bioactive compounds in atherosclerosis. International Journal of Molecular Sciences, v. 26, n. 3, 2025a. DOI: https://doi.org/10.3390/ijms26031379.
WU, S.; LIAO, X.; ZHU, Z.; et al. Antioxidant and anti-inflammation effects of dietary phytochemicals: the Nrf2/NF-κB signalling pathway and upstream factors of Nrf2. Phytochemistry, v. 204, p. 113429, 2022. DOI: https://doi.org/10.1016/j.phytochem.2022.113429.
Downloads
Publicado
Edição
Seção
Licença
Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
