POLYLAMININ AND NEUROREGENERATION: EXPERIMENTAL ADVANCES AND EMERGING CLINICAL PERSPECTIVES

Abstract

Polylaminin has emerged as an innovative biomaterial in neuroregeneration due to its ability to mimic the neural extracellular matrix and promote tissue repair. This chapter aims to analyze experimental advances involving polylaminin and discuss its emerging clinical perspectives, based on contributions from key researchers such as Timpl, Yurchenco, and Silva. The methodology consisted of a narrative review of recent scientific literature, including in vitro and in vivo studies. The results indicate that polylaminin enhances cell adhesion, neuronal differentiation, and axonal growth, while modulating inflammatory responses, as reported in studies on laminin and neural biomaterials. Experimental models of spinal cord injury show significant functional recovery associated with these compounds. However, challenges such as structural stability, standardization, and clinical validation remain. It is concluded that polylaminin represents a promising approach for regenerative therapies in the nervous system, with strong translational potential, although more robust clinical trials are still required.