TERAPIAS-ALVO EM ALTERAÇÕES MOLECULARES EMERGENTES (KRAS G12C, BRAF E HER2) NO CÂNCER DE CÓLON: BASES BIOLÓGICAS, EVIDÊNCIAS CLÍNICAS E IMPACTO NA MEDICINA DE PRECISÃO
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https://doi.org/10.63330/aurumpub.036-020Palabras clave:
BRAF V600E, Câncer de cólon, HER2, KRAS G12C, Medicina de precisãoResumen
O câncer de cólon apresenta elevada heterogeneidade molecular, sendo as alterações em KRAS G12C, BRAF V600E e HER2 determinantes na estratificação terapêutica e na consolidação da medicina de precisão. Este estudo teve como objetivo analisar as bases biológicas dessas alterações, as evidências clínicas relacionadas às terapias-alvo correspondentes e seu impacto na prática oncológica contemporânea. Trata-se de revisão bibliográfica qualitativa, realizada em bases de dados internacionais, com seleção de estudos publicados entre 2021 e 2026. Os resultados evidenciam que a mutação KRAS G12C, anteriormente considerada “indrogável”, tornou-se alvo terapêutico viável com o desenvolvimento de inibidores seletivos, especialmente eficazes quando combinados a anticorpos anti-EGFR, a fim de reduzir mecanismos de reativação compensatória. No subtipo BRAF V600E, estratégias combinatórias envolvendo inibidores de BRAF, MEK e bloqueio de EGFR demonstraram melhora significativa de sobrevida, redefinindo o padrão terapêutico para esse grupo de pior prognóstico. Já a amplificação ou superexpressão de HER2 configura subgrupo distinto, frequentemente resistente a terapias anti-EGFR isoladas, mas responsivo ao duplo bloqueio anti-HER2. Apesar dos avanços, a resistência primária e adquirida, associada à heterogeneidade tumoral e à plasticidade metabólica, permanece como desafio clínico relevante. Conclui-se que a integração entre biologia molecular, monitoramento genômico e estratégias combinatórias é essencial para otimizar desfechos e consolidar a medicina personalizada no câncer de cólon.
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Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
