ACUTE VERSUS CHRONIC REJECTION IN PEDIATRIC PATIENTS: BIOMARKERS AND NEW DIAGNOSTIC APPROACHES
DOI:
https://doi.org/10.63330/aurumpub.024-010Keywords:
Acute rejection, Biomarkers, Chronic rejection, Early diagnosis, PediatricsAbstract
This chapter aims to analyze the mechanisms involved in acute and chronic rejection in pediatric transplant patients, emphasizing the role of biomarkers and new diagnostic approaches. It is a descriptive literature review based on studies by authors such as Smith (2021), Johnson and Lee (2020), and Oliveira et al. (2023), which investigate immunological differences between rejection types and technological advances in early detection. The results indicate that acute rejection is characterized by rapid clinical manifestations linked to cellular activation, while chronic rejection is associated with persistent inflammatory processes and tissue fibrosis. The literature shows that biomarkers such as IL6, troponin, and microRNAs have the potential to improve outcome prediction and guide therapeutic decisions. It is concluded that the use of advanced diagnostic tools, combined with individualized monitoring, can enhance graft survival and improve the quality of life of children. The integration of diagnostic protocols based on biomarkers in pediatric transplant services is recommended.
Downloads
References
ARDIN, L. Análise de conteúdo. 1. ed. São Paulo: Edições 70, 2016.
GIL, A. C. Métodos e técnicas de pesquisa social. 7. ed. São Paulo: Atlas, 2022.
JOHNSON, M.; LEE, R. Chronic graft rejection in pediatric transplantation: immunological mechanisms and clinical management. Journal of Pediatric Transplantation, v. 18, n. 4, p. 220-228, 2020.
KITCHENHAM, B.; CHARTERS, S. Guidelines for performing systematic literature reviews in software engineering. Durham: EBSE Technical Report, 2007.
MARTÍNEZ, L. et al. Biomarkers and clinical monitoring in pediatric transplant outcomes. Clinical Transplant Review, v. 12, n. 2, p. 87-96, 2022.
OLIVEIRA, R. T. et al. Avanços em medicina de precisão no transplante pediátrico: o papel dos microRNAs no diagnóstico precoce. Revista Brasileira de Imunologia Clínica, v. 11, n. 1, p. 45-59, 2023.
SMITH, J. Early detection strategies for acute organ rejection in children. Pediatric Clinical Advances, v. 25, n. 3, p. 132-140, 2021.
SOUZA, D. R.; ALMEIDA, F. M. Protocolos de acompanhamento pós-transplante em pacientes pediátricos: avaliação clínica e perspectivas. Revista de Saúde e Pesquisa Médica, v. 15, n. 1, p. 101112, 2024.
YIN, R. K. Estudo de caso: planejamento e métodos. 6. ed. Porto Alegre: Bookman, 2015.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
