DIETARY PATTERNS AS AN INTERVENTION IN OXIDATIVE STRESS AND INFLAMMATION
DOI:
https://doi.org/10.63330/aurumpub.042-001Keywords:
Diet, Bioactive foods, Oxidative stressAbstract
Oxidative stress and chronic inflammation play a central role in the pathophysiology of several chronic diseases. In this context, bioactive compounds of dietary origin have been extensively investigated for their ability to modulate inflammatory and redox pathways. The literature indicates that compounds such as curcumin, gingerols, and sulfur compounds from garlic and tomatoes modulate inflammatory transcription factors and activate endogenous antioxidant systems. However, the effects observed in humans are heterogeneous, influenced by factors such as preparation method, dose, food matrix, and patient variability. Dietary patterns rich in plant-based foods containing multiple bioactive compounds are associated with improved markers related to oxidative stress and inflammation. Considering the complexity of the food matrix and human biological systems, the results reinforce the importance of an individualized dietary approach, rather than isolated supplementation of specific compounds, especially in the absence of standardization of effective doses.
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AL-MADHAGI, H.; MASOUD, A. Limitations and challenges of antioxidant therapy. Phytotherapy Research, v. 38, n. 12, p. 5549–5566, 2024. DOI: https://doi.org/10.1002/ptr.8335.
ANAND, P.; KUNNUMAKKARA, A. B.; NEWMAN, R. A.; AGGARWAL, B. B. Bioavailability of curcumin: problems and promises. Molecular Pharmaceutics, v. 4, n. 6, p. 807–818, 2007. DOI: https://doi.org/10.1021/mp700113r.
AVERILL-BATES, D. Reactive oxygen species and cell signaling. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, v. 1871, n. 2, p. 119573, 2024. DOI: https://doi.org/10.1016/j.bbamcr.2023.119573.
BISCHOFF-KONT, I.; FÜRST, R. Benefits of ginger and its constituent 6-shogaol in inhibiting inflammatory processes. Pharmaceuticals, v. 14, n. 6, 2021. DOI: https://doi.org/10.3390/ph14060571.
CAS, M. D.; GHIDONI, R. Dietary curcumin: correlation between bioavailability and health potential. Nutrients, v. 11, n. 9, 2019. DOI: https://doi.org/10.3390/nu11092147.
EDWARDS, R. L.; LUIS, P. B.; VARUZZA, P. V.; et al. The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites. Journal of Biological Chemistry, v. 292, n. 52, p. 21243–21252, 2017. DOI: https://doi.org/10.1074/jbc.RA117.000123.
EMRAN, T. B. Neuroprotective potential of epigallocatechin gallate in neurodegenerative diseases: insights into molecular mechanisms and clinical relevance. Brain Research, v. 1860, p. 149693, 2025. DOI: https://doi.org/10.1016/j.brainres.2025.149693.
FAGIANI, F.; CATANZARO, M.; BUOSO, E.; et al. Targeting cytokine release through the differential modulation of Nrf2 and NF-κB pathways by electrophilic/non-electrophilic compounds. Frontiers in Pharmacology, v. 11, 2020. DOI: https://doi.org/10.3389/fphar.2020.01256.
GADINA, M.; GAZANIGA, N.; VIAN, L.; FURUMOTO, Y. Small molecules to the rescue: inhibition of cytokine signaling in immune-mediated diseases. Journal of Autoimmunity, v. 85, p. 20–31, 2017. DOI: https://doi.org/10.1016/j.jaut.2017.06.006.
GARCIA, C.; BLESSO, C. N. Antioxidant properties of anthocyanins and their mechanism of action in atherosclerosis. Free Radical Biology and Medicine, v. 172, p. 152–166, 2021b. DOI: https://doi.org/10.1016/j.freeradbiomed.2021.05.040.
GONZÁLEZ, P.; LOZANO, P.; ROS, G.; SOLANO, F. Hyperglycemia and oxidative stress: an integral, updated and critical overview of their metabolic interconnections. International Journal of Molecular Sciences, v. 24, n. 11, 2023a. DOI: https://doi.org/10.3390/ijms24119352.
GUAN, R.; VAN LE, Q.; YANG, H.; et al. A review of dietary phytochemicals and their relation to oxidative stress and human diseases. Chemosphere, v. 271, p. 129499, 2021. DOI: https://doi.org/10.1016/j.chemosphere.2020.129499.
LEE, H,.; KAY, C.; ABDELHAMID, A.; et al. Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. The American Journal of Clinical Nutrition, v. 95, n. 3, p. 740–751, 2012. DOI: https://doi.org/10.3945/ajcn.111.023457.
ISLAM, M. R.; RAUF, A.; AKTER, S.; et al. Epigallocatechin 3-gallate-induced neuroprotection in neurodegenerative diseases: molecular mechanisms and clinical insights. Molecular and Cellular Biochemistry, v. 480, n. 6, p. 3363–3383, 2025. DOI: https://doi.org/10.1007/s11010-025-05211-4.
JOMOVA, K.; RAPTOVA, R.; ALOMAR, S. Y.; et al. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Archives of Toxicology, v. 97, n. 10, p. 2499–2574, 2023a. DOI: https://doi.org/10.1007/s00204-023-03562-9.
LIU, H.; JIAO, Y.; WANG, P. C.; et al. Oxidative stress and antioxidant therapeutic mechanisms. Pharmacology & Therapeutics, v. 278, p. 108962, 2026. DOI: https://doi.org/10.1016/j.pharmthera.2025.108962.
LÓPEZ-SOLÍS, R.; CASTRO-BARQUERO, S.; DONAT-VARGAS, C.; et al. Lycopene intake and prostate cancer risk in men at high cardiovascular risk: a prospective cohort study. BMC Medicine, v. 23, n. 1, 2025. DOI: https://doi.org/10.1186/s12916-025-04440-0
LUGRIN, J.; ROSENBLATT-VELIN, N.; PARAPANOV, R.; LIAUDET, L. The role of oxidative stress during inflammatory processes. Biological Chemistry, v. 395, n. 2, p. 203–230, 2014b. DOI: https://doi.org/10.1515/hsz-2013-0241.
ALLEN, L. H. Micronutrients assessment, requirements, deficiencies, and interventions. The New England Journal of Medicine, 2025. Disponível em: https://www.nejm.org. Acesso em: [dia mês ano].
MOHAMMADI, N.; FARRELL, M.; O’SULLIVAN, L.; et al. Effectiveness of anthocyanin-containing foods and nutraceuticals in mitigating oxidative stress, inflammation, and cardiovascular health-related biomarkers: a systematic review of animal and human interventions. Food & Function, v. 15, n. 7, p. 3274–3299, 2024. DOI: https://doi.org/10.1039/d3fo04579j
MORVARIDZADEH, M.; FAZELIAN, S.; AGAH, S.; et al. Effect of ginger (Zingiber officinale) on inflammatory markers: a systematic review and meta-analysis of randomized controlled trials. Cytokine, v. 135, p. 155224, 2020. DOI: https://doi.org/10.1016/j.cyto.2020.155224.
MOTA, J. C.; ALMEIDA, P. P.; FREITAS, M. Q.; et al. Far from being a simple question: the complexity between in vitro and in vivo responses from nutrients and bioactive compounds with antioxidant potential. Food Chemistry, v. 402, p. 134351, 2023. DOI: https://doi.org/10.1016/j.foodchem.2022.134351.
NAKADATE, K.; ITO, N.; KAWAKAMI, K.; YAMAZAKI, N. Anti-inflammatory actions of plant-derived compounds and prevention of chronic diseases: from molecular mechanisms to applications. International Journal of Molecular Sciences, v. 26, n. 11, 2025. DOI: https://doi.org/10.3390/ijms26115206.
OZKAN, G.; GÜNAL-KÖROĞLU, D.; KARADAG, A.; et al. A mechanistic updated overview on lycopene as potential anticancer agent. Biomedicine & Pharmacotherapy, v. 161, p. 114428, 2023. DOI: https://doi.org/10.1016/j.biopha.2023.114428.
PAUDEL, K. R.; ORENT, J.; PENELA, O. G. Pharmacological properties of ginger (Zingiber officinale): what do meta-analyses say? a systematic review. Frontiers in Pharmacology, v. 16, 2025. DOI: https://doi.org/10.3389/fphar.2025.1619655.
RAUTIAINEN, S.; SESSO, H. D.; MANSON, J. A. E. Large-scale randomized clinical trials of bioactives and nutrients in relation to human health and disease prevention: lessons from the VITAL and COSMOS trials. Molecular Aspects of Medicine, v. 61, p. 12–17, 2018. DOI: https://doi.org/10.1016/j.mam.2017.12.001.
RODRIGUEZ-MATEOS, A.; WEBER, T.; SKENE, S. S.; et al. Assessing the respective contributions of dietary flavanol monomers and procyanidins in mediating cardiovascular effects in humans: randomized, controlled, double-masked intervention trial. The American Journal of Clinical Nutrition, v. 108, n. 6, p. 1229–1237, 2018. DOI: https://doi.org/10.1093/ajcn/nqy229.
ROŞIAN, Ş. H.; BOARESCU, I.; BOARESCU, P. M. Antioxidant and anti-inflammatory effects of bioactive compounds in atherosclerosis. International Journal of Molecular Sciences, v. 26, n. 3, 2025a. DOI: https://doi.org/10.3390/ijms26031379.
WU, S.; LIAO, X.; ZHU, Z.; et al. Antioxidant and anti-inflammation effects of dietary phytochemicals: the Nrf2/NF-κB signalling pathway and upstream factors of Nrf2. Phytochemistry, v. 204, p. 113429, 2022. DOI: https://doi.org/10.1016/j.phytochem.2022.113429.
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