TRANSTORNO OPOSITOR DESAFIADOR (TOD): ASPECTOS NEUROBIOLOGICOS, DIAGNÓSTICOS E PERSPECTIVAS CLÍNICAS
DOI:
https://doi.org/10.63330/aurumpub.036-018Palabras clave:
Neurobiologia, Transtorno Opositor Desafiador, Disfunção do córtex pré-frontal, Regulação emocional, Comorbidades psiquiátricasResumen
O Transtorno Opositor Desafiador (TOD) é uma condição do neurodesenvolvimento caracterizada por padrão persistente de humor irritável, comportamento desafiador e atitudes vingativas. Embora frequentemente banalizado como “problema comportamental”, o TOD envolve alterações neurobiológicas mensuráveis, elevada carga familiar e importante impacto funcional. Este artigo revisa criticamente os fundamentos neurobiológicos, critérios diagnósticos, diagnósticos diferenciais, comorbidades, abordagens terapêuticas e limitações atuais da prática clínica.
Descargas
Referencias
1. Anderson JC, Williams S, McGee R, Silva PA. DSM-III disorders in Preadolescent children. Prevalence in a large sample from the general population. Arch Gen Psychiatry 1987;44(1):69-76.
2. Souza I, Serra MA, Mattos P, Franco VA. Comorbidade em crianças e adolescentes com transtorno do déficit de atenção: resultados preliminares. Arq Neuropsiquiatr. 2001; 59(2B):401-6.
3. Van Goozen SH, van den Ban E, Matthys W, Cohen-Kettenis PT,Thijssen JH, van Engeland H. Increased adrenal androgen functioning in children with oppositional defiant disorder: a comparison with psychiatric and normal controls. J Am Acad Child Adolesc Psychiatry.2000;39(11):1446-51.
4. Van Goozen SH, Matthys W, Cohen-Kettenis PT, Buitelaar JK, van engeland H. Hypothalamic-pituitary-adrenal axis and autonomic nervous system activity in disruptive children and matched controls. J Am Acad Child Adolesc Psychiatry. 2000; 39(11):1438-45.
5. Van Goozen SH, Matthys W, Cohen-Kettenis PT, Westenberg H, van engeland H. Plasma monoamine metabolites and aggression:two studies Of normal and oppositional defiant disorder children. Eur Neuropsychopharmacol. 1999; 9(1- 2):141-7.
6. Snoek H, van Goozen SH, Matthys W, Sigling HO, Koppeschaar HP, Westenberg HG, van Engeland H. Serotonergic functioning in children with oppositional defiant disorder: a sumatriptan challenge study. Biol psychiatry. 2002;51(4):319-25.
7. Clarke AR, Barry RJ, McCarthy R, Selikowitz M. Children with attention- deficit/hyperactivity disorder and comorbid oppositional defiant disorder:na EEG analysis. Psychiatry Res. 2002;111(2-3):181-90.
8. Kim MS, Kim JJ, Kwon JS. Frontal P300 decrement and executive dysfunction in adolescents with conduct problems. Child Psychiatry Hum dev. 2001;32(2):93-106.
9. Nadder TS, Rutter M, Silberg JL, Maes HH, Eaves LJ. Genetic effects ont he variation and covariation of attention-deficit-hyperactivity disorder (ADHD) and oppositional-defiant disorder/conduct disorder (Odd/CD) symptomatologies across informant and occasion of measurement. Psychol Med. 2002;32(1):39-53.
10. Comings DE, Wu S, Chiu C, Ring RH, Gade R, Ahn C, et al. Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: the additive and subtractive effect of the three dopaminergic genes—DRD2, D beta H, and DAT1. Am J Med Genet. 1996;67(3):264-88
Descargas
Publicado
Número
Sección
Licencia
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
