DESAFIOS CONTEMPORÂNEOS NO MANEJO DO DERRAME PLEURAL MALIGNO: AVANÇOS NO DIAGNÓSTICO, TRATAMENTO E PROGNÓSTICO
DOI:
https://doi.org/10.63330/aurumpub.068-060Palabras clave:
Biomarcadores, Diagnóstico, Derrame Pleural Maligno, Oncologia de Precisão, TratamentoResumen
O derrame pleural maligno constitui uma manifestação frequente de neoplasias avançadas e representa importante desafio clínico devido à complexidade diagnóstica, à recorrência e à heterogeneidade da resposta terapêutica. Este estudo teve como objetivo analisar os desafios contemporâneos e os avanços relacionados ao diagnóstico, tratamento e prognóstico do derrame pleural maligno. Realizou-se uma revisão integrativa da literatura, com buscas nas bases SciELO, Latindex, LILACS, Miguilim, PubMed e repositórios de periódicos vinculados ao Open Journal Systems (OJS), considerando publicações entre 2021 e 2026, nos idiomas português e inglês. Foram priorizados estudos relacionados à investigação diagnóstica, estratégias terapêuticas, biomarcadores, caracterização molecular, prognóstico e cuidados individualizados. Os achados demonstraram que a citologia do líquido pleural permanece relevante, embora apresente limitações que justificam a utilização de métodos complementares. Observou-se crescimento do interesse por biomarcadores, análises bioquímicas, caracterização molecular e ferramentas de oncologia de precisão. No tratamento, evidenciou-se a necessidade de integrar intervenções pleurais ao controle da neoplasia subjacente, considerando características clínicas, funcionais e biológicas. Conclui-se que o manejo contemporâneo do derrame pleural maligno requer abordagem multidisciplinar, individualizada e centrada no paciente, associando precisão diagnóstica, estratégias terapêuticas personalizadas e avaliação prognóstica contínua. Novos estudos prospectivos multicêntricos são necessários para validar biomarcadores e modelos preditivos aplicáveis à prática clínica.
Descargas
Referencias
ADDALA, D. et al. Malignant pleural effusion: updates in diagnosis, management and current challenges. Frontiers in Oncology, v. 12, 2022.
ALEKSIEV, V. et al. Enhanced diagnostic approaches for malignant pleural effusions: an extensive biochemical and statistical analysis. Folia Medica, v. 67, n. 2, 2025.
AULIYA, H. et al. Diagnosis and management of malignant pleural effusion: a narrative literature review. Bioscientia Medicina: Journal of Biomedicine and Translational Research, 2022.
BASHOUR, S. et al. Update on the diagnosis and management of malignant pleural effusions. Respiratory Medicine, v. 196, p. 106802, 2022.
BEDAWI, E. et al. Advances in pleural infection and malignancy. European Respiratory Review, v. 30, 2021.
CUI, S.-T. et al. Unraveling the multidimensional pleural ecosystem of lung cancer-associated malignant pleural effusion. Cancer Cell International, v. 26, 2026.
DAMIANI, D. et al. Turning fluids into data for precision oncology: a multidisciplinary tumor board approach to malignant pleural effusions. Biomedicines, v. 14, 2026.
GAYEN, S. Malignant pleural effusion: presentation, diagnosis, and management. The American Journal of Medicine, 2022.
GOKCE, A.; AKBOĞA, S. Managing malignant pleural effusions: a single center’s experience. Medicine Science-International Medical Journal, 2022.
GONNELLI, F. et al. Malignant pleural effusion: current understanding and therapeutic approach. Respiratory Research, v. 25, 2024.
HUGHES, S. M.; CARMICHAEL, J. Malignant pleural effusions: updates in diagnosis and management. Life, v. 13, 2022.
KARCİOĞLU, O. et al. Malignant pleural effusions: are we better than the past? Acta Medica, 2024.
KARINA, T. R. et al. Malignant pleural effusion: a contemporary approach to diagnosis and personalized management. Respiratory Science, 2026.
KULANDAISAMY, P. et al. Malignant pleural effusions—a review of current guidelines and practices. Journal of Clinical Medicine, v. 10, 2021.
MOHAMMED, A. et al. Management of malignant pleural effusion—a case-based tailored approach. PAIRS 2023 Annual Congress, 2023.
MUNAVVAR, M. et al. Current trends in treating malignant pleural effusion: evidence, guidelines, and best practice recommendations. JCO Oncology Practice, v. 21, p. 759-765, 2024.
ORLANDI, R. et al. Malignant pleural effusion: diagnosis and treatment—up-to-date perspective. Current Oncology, v. 31, p. 6867-6878, 2024.
SANTOTORIBIO, J. D. Pleural fluid biomarkers for the diagnosis and management of malignant pleural effusions: a clinical review. Critical Reviews in Clinical Laboratory Sciences, v. 63, p. 237-260, 2025.
SCHWALK, A. et al. Analysis of pleural fluid biomarkers for diagnosis of malignant pleural effusion and molecular characterization of lung cancer: a review. Current Opinion in Pulmonary Medicine, 2026.
SCOTT, H.; PHIL, R. What you need to know about: the management of malignant pleural effusion. British Journal of Hospital Medicine, v. 85, n. 12, p. 1-18, 2024.
SHOJAEЕ, S. et al. Cytologic investigations for the diagnosis of malignant pleural effusion in non-small cell lung cancer. Journal of Bronchology & Interventional Pulmonology, v. 28, p. 310-321, 2021.
SHORTHOSE, M. et al. A patient-centred approach to malignant pleural effusion. European Clinical Respiratory Journal, v. 12, 2025.
SPISAROVÁ, M. et al. Pleural effusion as a sample matrix for laboratory analyses in cancer management: a perspective. Clinical Chemistry and Laboratory Medicine (CCLM), v. 63, p. 1069-1074, 2025.
WESTLEY, R. et al. Updates in the management of malignant pleural effusion: a clinical practice review. Journal of Thoracic Disease, v. 17, p. 6283-6295, 2025.
WONG, T. et al. Malignant pleural effusions in the era of immunotherapy and antiangiogenic therapy. Seminars in Respiratory and Critical Care Medicine, v. 44, p. 447-453, 2023.
YANG, L.-L.; WANG, Y. Malignant pleural effusion diagnosis and therapy. Open Life Sciences, v. 18, 2023.
ZHAO, Y. et al. Current status of and progress in the treatment of malignant pleural effusion of lung cancer. Frontiers in Oncology, v. 12, 2023
Descargas
Publicado
Número
Sección
Licencia
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
