COLLAGEN BIOSTIMULATORS IN THE FACIAL AND BODY REGIONS: MECHANISMS OF ACTION, CLINICAL EVIDENCE, AND THERAPEUTIC SAFETY
DOI:
https://doi.org/10.63330/aurumpub.068-008Keywords:
Aesthetics, Biostimulation, Collagen, Tissue regeneration, Tissue remodelingAbstract
Collagen biostimulators are resources used in aesthetics to stimulate biological responses associated with collagen production and remodeling, contributing to tissue quality and structure. This study aimed to gather, analyze, and synthesize scientific evidence on the mechanisms of action of collagen biostimulators and their potential applications in facial and body aesthetics. This is an integrative literature review with a qualitative and exploratory approach, conducted between July and August 2026 using the PubMed/MEDLINE and ScienceDirect databases. Articles published between 2021 and 2025 were considered, with 12 studies selected after applying the inclusion and exclusion criteria. The results demonstrated different biostimulation mechanisms, including fibroblast activation, stimulation of neocollagenesis, macrophage modulation, angiogenesis, reduction of inflammatory processes, and tissue regeneration. Evidence related to extracellular matrix preservation and improvement of characteristics associated with skin aging was also identified. However, the findings reinforce the need for individualized assessment, appropriate indication, professional monitoring, and compliance with health regulations. It is concluded that collagen biostimulators have potential to promote tissue remodeling and regeneration, although further clinical studies are necessary to expand the understanding of their safety, effectiveness, and aesthetic applicability.
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