THE ROLE OF SYSTEMIC INFLAMMATION IN THE PATHOPHYSIOLOGY OF DEPRESSION: A NEUROPSYCHIATRIC STUDY
DOI:
https://doi.org/10.63330/aurumpub.049-016Keywords:
Depression, Systemic inflammation, Neuroinflammation, Cytokines, NeuropsychiatryAbstract
Introduction: Depression is a multifactorial disorder whose pathophysiology involves interactions between neurobiological and immunological systems. Recent evidence points to systemic inflammation as one of the mechanisms involved. Objective: To critically analyze the role of systemic inflammation in the pathophysiology of depression from a neuropsychiatric perspective. Methods: Narrative literature review based on studies published in the last 15 years in databases such as PubMed, SciELO, and LILACS. Results: An association was observed between increased pro-inflammatory cytokines and alterations in neurotransmission, hyperactivity of the hypothalamic-pituitary-adrenal axis, and reduced neuroplasticity. However, this association is not universal among depressed patients. Conclusion: Systemic inflammation contributes to the pathophysiology of depression in specific subgroups, but should not be considered a single or central mechanism in all cases.
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