ADVANCES IN THE USE OF COLLAGEN BIOSTIMULATORS FOR SKIN REJUVENATION AND FIRMING

Abstract

Aesthetic biomedicine has stood out for developing safe and effective techniques aimed at rejuvenation and improving skin quality. Among these innovations, collagen biostimulators stand out for stimulating the natural production of this protein, promoting firmness, elasticity, and progressive, natural results. Substances such as poly-L-lactic acid, calcium hydroxyapatite, and polycaprolactone have demonstrated proven efficacy and clinical safety. The growing demand for minimally invasive procedures reinforces this global trend. Conducted between March and April 2025, the study reviewed literature from Google Scholar, SciELO, and PubMed databases, without language restrictions, covering articles published from 2019 to 2024. The descriptors “Collagen,” “Rejuvenation,” and “Biostimulants” were used, combined with Boolean operators, and inclusion criteria considered full-text availability, thematic relevance, and methodological rigor. The results indicated that PLLA, CaHA, and PCL promoted neocollagenesis, dermal thickening, and improvements in firmness, elasticity, and texture, with progressive and long-lasting effects (up to 24 months), superior to immediate correction materials. A favorable benefit–risk ratio was observed when clinical evaluation, agent selection, and application technique were properly followed. Positive psychosocial impacts (self-image and well-being) and versatility in facial and body applications were also noted. However, gaps remain regarding protocol standardization, objective outcome metrics, and direct comparisons between agents. It is concluded that collagen biostimulators represent a safe and effective tool aligned with integrative and preventive aesthetics, offering valuable clinical indicators for different biotypes.