THE LEADING ROLE OF VITAMIN C AND ITS PHARMACOLOGICAL REPOSITIONING DURING THE COVID-19 PERIOD: SCIENTIFIC EVIDENCE versus FAKE NEWS

Autores/as

  • Railson Pereira Souza Autor
  • Jorgiana Araújo Libânio Autor
  • Kauan Ferreira da Rocha Autor
  • Renata Sales Abreu Formiga Autor
  • Ianne Fernandes da Silva Autor
  • Vanessa Maria Oliveira Viana Autor
  • Antonio Jalson Cardoso Magalhães Autor
  • Vanessa Barros Trindade Lima Fernandes Autor
  • Crislane de Moura Costa Autor
  • Marilene Magalhães de Brito Autor
  • Paulo Victor de Lima Sousa Autor

DOI:

https://doi.org/10.63330/aurumpub.044-021

Palabras clave:

Vitamin C, COVID-19, Drug repositioning, Fake news, Health education

Resumen

The present study addresses the analysis of the quality of scientific evidence related to the pharmacological leading role of vitamin C and its repositioning in the context of COVID-19, in the face of the dissemination of misinformation in digital environments. This is a bibliographic review whose objective was to critically evaluate the therapeutic role of ascorbic acid, as well as to confront unsupported information widely disseminated during the pandemic. The methodology was based on the search for and analysis of scientific articles, clinical trials, and technical documents available in databases such as PubMed, Web of Science, ScienceDirect, and Embase, as well as preprint repositories and clinical study registries. The results show that vitamin C has relevant antioxidant, anti-inflammatory, and immunomodulatory properties and may act as adjuvant therapy in patients with severe conditions, especially in reducing hospitalization time and improving clinical parameters. However, it was observed that the evidence remains inconclusive regarding its isolated efficacy in the treatment of COVID-19, especially due to the heterogeneity of the studies and the lack of definition of ideal doses. Furthermore, the widespread dissemination of false information associating vitamin C with curing the disease was identified, which may compromise evidence-based prevention measures. It is concluded that, although promising, the use of vitamin C should be guided by robust scientific evidence, and the strengthening of health education strategies is essential for confronting misinformation.

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Referencias

AKODAD, S. et al. Impact of drug repurposing between 1985 and 2024 on pharmaceutical innovation. Communications Medicine, v. 6, n. 1, p. 84, 2026.

ALBERTS, A. et al. Vitamin C: a comprehensive review of its role in health, disease prevention, and therapeutic potential. Molecules, v. 30, n. 3, p. 748, 2025.

ANDERSON, O. S. Intravenous ascorbic acid for supportive treatment in hospitalized COVID-19 patients. Journal of Orthomolecular Medicine, v. 35, n. 1, p. 1–3, 2020.

AUGUSTIN, Y. et al. Drug repurposing for COVID-19: current evidence from randomized controlled adaptive platform trials and living systematic reviews. British Medical Bulletin, v. 147, n. 1, p. 31–49, 2023.

BALADIA, E. et al. Vitamin C for the treatment of COVID-19: a living systematic review. Medwave, v. 20, n. 6, e978, 2020.

BENDIB, I. et al. Neutrophil extracellular traps are elevated in patients with pneumonia-related acute respiratory distress syndrome. Anesthesiology, v. 130, n. 4, p. 581–591, 2019.

BHARARA, A. et al. Intravenous vitamin C administered as adjunctive therapy for recurrent acute respiratory distress syndrome. Case Reports in Critical Care, v. 2016, p. 8560871, 2016.

BORETTI, A.; BANIK, B. K. Intravenous vitamin C for reduction of cytokine storm in acute respiratory distress syndrome. PharmaNutrition, v. 12, p. 100190, 2020.

BRASIL. Ministério da Saúde. Saúde sem fake news. 2020. Disponível em: https://www.saude.gov.br/fakenews. Acesso em: 06 jul. 2020.

BRISOLA, A. C.; ROMEIRO, N. L. A competência crítica em informação como resistência. Revista Brasileira de Biblioteconomia e Documentação, São Paulo, 2018.

CARR, A. C. A new clinical trial to test high-dose vitamin C in patients with COVID-19. Critical Care, v. 24, n. 1, 2020.

CARVALHO, M. F. C.; MATEUS, C. A. Fake news e desinformação no meio digital. Múltiplos Olhares em Ciência da Informação, 2018.

CHEN, E.; LERMAN, K.; FERRARA, E. Tracking social media discourse about the COVID-19 pandemic. JMIR Public Health and Surveillance, v. 6, n. 2, 2020.

CHEN, N. et al. Epidemiological and clinical characteristics of COVID-19. The Lancet, v. 395, p. 507–513, 2020.

CHEN, T.; GUESTRIN, C. XGBoost: a scalable tree boosting system. In: Proceedings of the 22nd ACM SIGKDD Conference, 2016. p. 785–794.

CHENG, R. Can early and high intravenous dose of vitamin C prevent COVID-19? Medicine in Drug Discovery, p. 100028, 2020.

COMBS, G. F.; MCCLUNG, J. P. Vitamin C. In: The Vitamins. 5. ed. Academic Press, 2017. p. 267–295.

DEL RIO, C.; MALANI, P. N. 2019 novel coronavirus—important information for clinicians. JAMA, 2020.

DENNIS, J. M.; WITTING, P. K. Papel protetor dos antioxidantes. Nutrients, v. 9, p. E718, 2017.

DONG, E.; DU, H.; GARDNER, L. An interactive dashboard to track COVID-19. The Lancet Infectious Diseases, v. 20, n. 5, 2020.

FARHOUDINIA, B.; OZTURKCAN, S.; KASAP, N. Emotions unveiled: detecting COVID-19 fake news. Humanities and Social Sciences Communications, v. 11, p. 640, 2024.

GIOTAKOS, O. Fake news in the age of COVID-19. Psychiatriki, v. 33, n. 3, p. 183–186, 2022.

GÓMEZ, E. et al. Does vitamin C prevent the common cold? Medwave, v. 18, n. 4, 2018.

GUARIENTI, F. A. et al. COVID-19: a multi-organ perspective. Frontiers in Cellular and Infection Microbiology, v. 14, 2024.

HEMILÄ, H.; CHALKER, E. Vitamin C can shorten ICU stay. Nutrients, v. 11, p. 708, 2019.

HOOK, J. L.; KUEBLER, W. M. CFTR as a therapeutic target. American Journal of Physiology, v. 328, n. 2, p. L229–L238, 2025.

HUANG, C. et al. Clinical features of COVID-19. The Lancet, v. 395, p. 497–506, 2020.

KASHIOURIS, M. G. et al. Vitamin C as treatment for sepsis. Nutrients, v. 12, p. 292, 2020.

KIM, W. Y. et al. Vitamin C, hydrocortisone and thiamine therapy. Journal of Critical Care, v. 47, p. 211–218, 2018.

LAI, C. C. et al. SARS-CoV-2 and COVID-19. International Journal of Antimicrobial Agents, v. 55, 2020.

LI, Q. et al. Early transmission dynamics of COVID-19. New England Journal of Medicine, v. 382, p. 1199–1207, 2020.

LU, H. Drug treatment options for COVID-19. Bioscience Trends, v. 14, n. 1, p. 69–71, 2020.

MA, K. C. et al. Estimated effectiveness of COVID-19 vaccination. JAMA Network Open, v. 9, n. 2, e2557415, 2026.

MERCORELLI, B. et al. Drug repurposing for viral diseases. Trends in Microbiology, v. 26, n. 10, p. 865–876, 2018.

NEUBERGER, A. et al. Renovation as innovation. Drug Discovery Today, v. 24, n. 1, p. 1–3, 2019.

OH, D. Y. et al. SARS-CoV-2 evolution and surveillance. Communications Medicine, v. 5, n. 1, p. 468, 2025.

PUSHPAKOM, S. et al. Drug repurposing: progress and challenges. Nature Reviews Drug Discovery, v. 18, n. 1, p. 41–58, 2018.

QIN, M. et al. Effects of vitamin C supplements on COVID-19. Nutrition Reviews, v. 83, n. 7, p. e1406–e1420, 2025.

ROSA, S. G. V.; SANTOS, W. C. Drug repositioning for COVID-19. Revista Panamericana de Salud Pública, v. 44, 2020.

SILVA, G. M. et al. COVID-19 vaccination challenges. Ciência & Saúde Coletiva, v. 28, n. 3, p. 739–748, 2023.

SINGH, M. et al. Drug repurposing for SARS-CoV-2. Frontiers in Pharmacology, v. 16, 2025.

VERMA, K. et al. Vitamin C in fruits and vegetables. Food Chemistry, v. 505, p. 148058, 2026.

WORLD HEALTH ORGANIZATION (WHO). Coronavirus disease (COVID-19). 2020.

ZENG, Y. et al. High-dose vitamin C in sepsis. Medicine, v. 102, n. 42, e35648, 2023.

ZHOU, F. et al. Clinical course and mortality of COVID-19. The Lancet, v. 395, p. 1054–1062, 2020.

ZHU, N. et al. A novel coronavirus from patients with pneumonia. New England Journal of Medicine, 2020.

Publicado

2026-05-04

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Cómo citar

Souza, R. P., Libânio, J. A., da Rocha, K. F., Formiga, R. S. A., da Silva, I. F., Viana, V. M. O., Magalhães, A. J. C., Fernandes, V. B. T. L., Costa, C. de M., de Brito, M. M., & Sousa, P. V. de L. (2026). THE LEADING ROLE OF VITAMIN C AND ITS PHARMACOLOGICAL REPOSITIONING DURING THE COVID-19 PERIOD: SCIENTIFIC EVIDENCE versus FAKE NEWS. Aurum Editora, 256-273. https://doi.org/10.63330/aurumpub.044-021