TIRZEPATIDE AND MODULATION OF THE REWARD SYSTEM: PHYSIOPATHOLOGICAL BASES AND IMPLICATIONS IN SUBSTANCE USE DISORDER
DOI:
https://doi.org/10.63330/aurumpub.049-028Keywords:
Tirzepatide, GLP-1, GIP, Reward system, Substance dependence, DopamineAbstract
Tirzepatide, a dual agonist of GLP-1 and GIP receptors, has demonstrated robust metabolic effects in the treatment of type 2 diabetes mellitus and obesity. Emerging evidence suggests that incretin agonists also modulate the brain's reward system, influencing addictive behaviors. This review critically analyzes the pathophysiological mechanisms involved in the interaction between the gut-brain axis and mesolimbic dopaminergic circuits, as well as its potential applicability in substance use disorder (SUD). Despite promising results in preclinical models and observational studies, the absence of randomized clinical trials limits its incorporation into clinical practice. Current interpretation should be cautious, considering the risk of biases and indirect mechanisms of action.
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