EPIGENETIC ALTERATIONS ASSOCIATED WITH DEEP ENDOMETRIOSIS: A LITERATURE REVIEW
DOI:
https://doi.org/10.63330/aurumpub.036-034Keywords:
Deep endometriosis, Epigenetics, DNA methylation, MicroRNAAbstract
Deep endometriosis is an infiltrative form of endometriosis associated with chronic pelvic pain, infertility, and reduced quality of life. Recent evidence indicates that epigenetic mechanisms play an important role in the pathophysiology of the disease. Therefore, this study aimed to analyze the main epigenetic alterations associated with deep endometriosis. This is a narrative literature review with a qualitative approach, conducted through searches in the PubMed, Scopus, SciELO, and Google Scholar databases using descriptors related to endometriosis and epigenetics. Articles published between 2007 and 2024 addressing DNA methylation, histone modifications, and microRNAs were included. The analyzed studies indicate that epigenetic alterations contribute to progesterone resistance, increased local steroidogenesis, persistent inflammation, and survival of endometriotic cells. It is concluded that these mechanisms play a central role in the progression of deep endometriosis and may represent potential diagnostic biomarkers and therapeutic targets.
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References
BEDRICK, B. S. et al. A systematic review of epigenetics of endometriosis. F&S Reviews, v. 5, n. 1, p. 100070, jan. 2024. DOI: 10.1016/j.xfnr.2024.01.003.
GUO, S.-W. Epigenetics of endometriosis. Molecular Human Reproduction, Oxford, v. 15, n. 10, p. 587–607, 2009. DOI: 10.1093/molehr/gap064.
OHLSSON TEAGUE, E. M. C. et al. MicroRNA-regulated pathways associated with endometriosis. Molecular Endocrinology, Chevy Chase, v. 23, n. 2, p. 265–275, 2009. DOI: 10.1210/me.2008-0387.
HON, J.-X. et al. MicroRNAs in Endometriosis: Insights into Inflammation and Progesterone Resistance. International Journal of Molecular Sciences, v. 24, n. 19, p. 15001, 9 out. 2023. DOI: 10.3390/ijms241915001.
HSIAO, K.-Y. et al. Epigenetic regulation of the pathological process in endometriosis. American Journal of Reproductive Immunology, v. 78, n. 2, e12680, 2017. DOI: 10.1111/aji.12680.
NASU, K. et al. Aberrant DNA methylation status of endometriosis: epigenetics as the pathogenesis, biomarker and therapeutic target. Journal of Obstetrics and Gynaecology Research, v. 37, n. 7, p. 683–695, 2011. DOI: 10.1111/j.1447-0756.2011.01598.x.
NASU, K. et al. Aberrant histone modification in endometriosis. Frontiers in Bioscience (Landmark Edition), v. 19, p. 1390–1397, jun. 2014. DOI: 10.2741/4285.
OHLSSON TEAGUE, E. M. C. et al. MicroRNA-regulated pathways associated with endometriosis. Molecular Endocrinology, Chevy Chase, v. 23, n. 2, p. 265–275, 2009. DOI: 10.1210/me.2008-0387.
PENNA, I. A. et al. Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4. The Journal of Clinical Endocrinology & Metabolism, v. 102, n. 1, p. 141–151, jan. 2017. DOI: 10.1210/jc.2016-2076.
ROSSI, M. et al. Epigenetics, endometriosis and sex steroid receptors: na update on the epigenetic regulatory mechanisms of estrogen and progesterone receptors in patients with endometriosis. Vitamins and Hormones, v. 122, p. 171–191, 2023. DOI: 10.1016/bs.vh.2023.01.007.
SHU, J. et al. Leveraging epigenetic aberrations in the pathogenesis of endometriosis: from DNA methylation to non-coding RNAs. Frontiers in Genetics, v. 14, 2023. DOI: 10.3389/fgene.2023.1151583.
XUE, Q. et al. Aberrant DNA methylation of the progesterone receptor gene in endometriosis. Biology of Reproduction, Madison, v. 77, n. 4, p. 681–687, 2007. DOI: 10.1095/biolreprod.107.060418.
ZONDERVAN, K. T. et al. Endometriosis. Nature Reviews Disease Primers, London, v. 4, n. 9, 2018. DOI: 10.1038/s41572-018-0008-5.
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