DETERMINING FACTORS AND IMPLICATIONS FOR NEURODEVELOPMENT IN ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY

Authors

  • Wilson Foré Autor
  • Maria Clara Santos Lacerda Autor
  • Louise Madalena Siquara Gomes Autor
  • Julia Arruda da Costa Galvão Autor
  • Felipe Skiresinski Gonçalves de Oliveira Autor
  • Carlos de Oliveira Farias Júnior Autor
  • Milton Jorge de Carvalho Filho Autor
  • Jeremias Nogueira Ramos Florenzano Autor
  • Diogo Gabriel Florindo Autor
  • João Enzio Gomes Autor
  • Rafael Kubo Ugatti de Souza Autor
  • Edvaldo Santana Pereira Junior Autor

DOI:

https://doi.org/10.63330/aurumpub.036-013

Keywords:

ADHD, Neurodevelopment, Multifactorial etiology, Executive functions, Neurobiology, Behavioral genetics

Abstract

Attention Deficit Hyperactivity Disorder (ADHD) is a complex neurodevelopmental condition characterized by persistent inattention, hyperactivity and impulsivity, with significant functional impact. The etiology is multifactorial, involving dynamic interaction between genetic, neurobiological, environmental and psychosocial factors. Contemporary evidence demonstrates changes in frontostriatal circuits, dopaminergic dysfunction and cortical maturational delay, with repercussions on executive functions, emotional regulation and academic-social performance. This article expands the analysis of etiological determinants and critically discusses their implications throughout neurodevelopment, including comorbidities, emerging biomarkers, evolutionary trajectories and functional impact throughout life.

Downloads

Download data is not yet available.

References

1. AMERICAN PSYCHIATRIC ASSOCIATION. Diagnostic and Statistical Manual of Mental Disorders: DSM-5-TR. 5. Ed. Washington, DC: American Psychiatric Publishing, 2022.

2. FARAONE, Stephen V. et al. Attention-deficit/hyperactivity disorder. Nature Reviews Disease Primers, London, v. 1, p. 15020, 2015.

3. POLANCZYK, Guilherme et al. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. American Journal of Psychiatry, Washington, v. 164, n. 6, p. 942–948, 2007.

4. CORTese, Samuele et al. Association between ADHD and obesity: a systematic review and meta-analysis. American Journal of Psychiatry, Washington, v. 173, n. 1, p. 34–43, 2016.

5. SHAW, Philip et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proceedings of the National Academy of Sciences, Washington, v. 104, n. 49, p. 19649–19654, 2007.

6. BARKLEY, Russell A. Attention-Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment. 4. Ed. New York: Guilford Press, 2015.

7. FARAONE, Stephen V.; LARSSON, Henrik. Genetics of attention deficit hyperactivity disorder. Molecular Psychiatry, London, v. 24, p. 562–575, 2019.

8. CORTese, Samuele et al. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder. The Lancet Psychiatry, London, v. 5, n. 9, p. 727–738, 2018.

9. SONUGA-BARKE, Edmund J. S. et al. Annual Research Review: Nonpharmacological interventions for ADHD. Journal of Child Psychology and Psychiatry, Oxford, v. 54, n. 3, p. 275–299, 2013.

10. THAPAR, Anita; COOPER, Miriam. Attention deficit hyperactivity disorder. The Lancet, London, v. 387, n. 10024, p. 1240–1250, 2016.

Published

2026-02-13

How to Cite

DETERMINING FACTORS AND IMPLICATIONS FOR NEURODEVELOPMENT IN ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY. (2026). Aurum Editora, 100-108. https://doi.org/10.63330/aurumpub.036-013

Publications by the same author