POLYENDOCRINE METABOLIC OVARIAN SYNDROME AND WOMEN’S HOLISTIC HEALTH: INTERFACES BETWEEN HORMONAL DYSFUNCTION, METABOLISM, AND FERTILITY
DOI:
https://doi.org/10.63330/aurumpub.070-007Keywords:
Gut microbiota, Hyperandrogenism, Insulin resistance, Mitochondrial dysfunction, Quality of lifeAbstract
Polyendocrine Metabolic Ovarian Syndrome (PMOS) has manifestations that extend beyond the reproductive system, involving metabolic, inflammatory, intestinal, and cellular alterations. This study aimed to analyze the condition’s main pathophysiological interfaces and their repercussions on ovarian function and women’s quality of life. This qualitative, exploratory integrative literature review was conducted in the PubMed/MEDLINE, Scopus, Web of Science, and Embase databases and considered publications from 2021 to 2026. Following the identification, screening, and eligibility stages, 17 studies were included. The studies demonstrated relationships among insulin resistance, hyperandrogenism, gut dysbiosis, inflammation, and altered ovarian function. Mitochondrial alterations, NAD⁺ deficiency, and impaired communication between the oocyte and granulosa cells were also identified and associated with impaired follicular development and oocyte competence. Experimental and clinical studies further indicated potential effects of nutritional interventions, bioactive compounds, and microbiota-targeted strategies. Therefore, an integrated understanding of the mechanisms involved may support more individualized approaches to prevention and care that consider the condition’s metabolic, reproductive, and psychosocial dimensions.
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References
BARDIN, L. Análise de conteúdo. São Paulo: Edições 70, 2011.
CAO, M. et al. Adipose mesenchymal stem cell-derived exosomal microRNAs ameliorate polycystic ovary syndrome by protecting against metabolic disturbances. Biomaterials, v. 288, p. 121739, 2022. DOI: https://doi.org/10.1016/j.biomaterials.2022.121739. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0142961222003799?via%3Dihub. Acesso em: 4 ago. 2026.
CHEN, M. et al. Resveratrol ameliorates polycystic ovary syndrome via transzonal projections within oocyte-granulosa cell communication. Theranostics, v. 12, n. 2, p. 782–795, 2022. DOI: https://doi.org/10.7150/thno.67167. Disponível em: https://www.thno.org/v12p0782.htm. Acesso em: 4 ago. 2026.
CINCIONE, R. I. et al. Effects of mixed of a ketogenic diet in overweight and obese women with polycystic ovary syndrome. International Journal of Environmental Research and Public Health, v. 18, n. 23, p. 12490, 2021. DOI: https://doi.org/10.3390/ijerph182312490. Disponível em: https://www.mdpi.com/1660-4601/18/23/12490. Acesso em: 4 ago. 2026.
FARHADI-AZAR, M. et al. The prevalence of polycystic ovary syndrome, its phenotypes and cardio-metabolic features in a community sample of Iranian population: Tehran Lipid and Glucose Study. Frontiers in Endocrinology, v. 13, 2022. DOI: https://doi.org/10.3389/fendo.2022.825528. Disponível em: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.825528/full. Acesso em: 4 ago. 2026.
GIL, A. C. Métodos e técnicas de pesquisa social. 6. ed. São Paulo: Atlas, 2008.
HAN, Q. et al. Androgen-induced gut dysbiosis disrupts glucolipid metabolism and endocrinal functions in polycystic ovary syndrome. Microbiome, v. 9, p. 101, 2021. DOI: https://doi.org/10.1186/s40168-021-01046-5. Disponível em: https://link.springer.com/article/10.1186/s40168-021-01046-5. Acesso em: 4 ago. 2026.
LI, C. et al. Eight-hour time-restricted feeding improves endocrine and metabolic profiles in women with anovulatory polycystic ovary syndrome. Journal of Translational Medicine, v. 19, p. 148, 2021a. DOI: https://doi.org/10.1186/s12967-021-02817-2. Disponível em: https://link.springer.com/article/10.1186/s12967-021-02817-2. Acesso em: 4 ago. 2026.
LI, T. et al. Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction. Redox Biology, v. 41, p. 101886, 2021b. DOI: https://doi.org/10.1016/j.redox.2021.101886. Disponível em: https://www.sciencedirect.com/science/article/pii/S2213231721000343?via%3Dihub. Acesso em: 4 ago. 2026.
LIANG, Z.; DI, N.; LI, L.; YANG, D. Gut microbiota alterations reveal potential gut–brain axis changes in polycystic ovary syndrome. Journal of Endocrinological Investigation, v. 44, p. 1727–1737, 2021. DOI: https://doi.org/10.1007/s40618-020-01481-5. Disponível em: https://link.springer.com/article/10.1007/s40618-020-01481-5. Acesso em: 4 ago. 2026.
LIAO, B. et al. Effects of androgen excess-related metabolic disturbances on granulosa cell function and follicular development. Frontiers in Endocrinology, v. 13, 2022. DOI: https://doi.org/10.3389/fendo.2022.815968. Disponível em: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.815968/full. Acesso em: 4 ago. 2026.
PRATAMA, G. et al. Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis. Scientific Reports, v. 14, p. 8229, 2024. DOI: https://doi.org/10.1038/s41598-024-58064-0. Disponível em: https://www.nature.com/articles/s41598-024-58064-0. Acesso em: 4 ago. 2026.
QIAN, Y. et al. Integrated lipid metabolomics and proteomics analysis reveal the pathogenesis of polycystic ovary syndrome. Journal of Translational Medicine, v. 22, p. 364, 2024. DOI: https://doi.org/10.1186/s12967-024-05167-x. Disponível em: https://link.springer.com/article/10.1186/s12967-024-05167-x. Acesso em: 4 ago. 2026.
TABASSUM, F. et al. Impact of polycystic ovary syndrome on quality of life of women in correlation to age, basal metabolic index, education and marriage. PLOS ONE, v. 16, n. 3, p. e0247486, 2021. DOI: https://doi.org/10.1371/journal.pone.0247486. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247486. Acesso em: 4 ago. 2026.
WANG, Y. et al. NAD+ deficiency and mitochondrial dysfunction in granulosa cells of women with polycystic ovary syndrome. Biology of Reproduction, v. 105, n. 2, p. 371–380, 2021. DOI: https://doi.org/10.1093/biolre/ioab078. Disponível em: https://academic.oup.com/biolreprod/article-abstract/105/2/371/6288483?redirectedFrom=fulltext. Acesso em: 4 ago. 2026.
YU, O. et al. Incidence, prevalence, and trends in polycystic ovary syndrome diagnosis: a United States population-based study from 2006 to 2019. American Journal of Obstetrics and Gynecology, v. 229, n. 1, p. 39.e1–39.e12, 2023. DOI: https://doi.org/10.1016/j.ajog.2023.04.010. Disponível em: https://www.ajog.org/article/S0002-9378(23)00241-7/abstract. Acesso em: 4 ago. 2026.
YUN, C. et al. The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice. Nature Metabolism, v. 6, p. 947–962, 2024. DOI: https://doi.org/10.1038/s42255-024-01041-8. Disponível em: https://www.nature.com/articles/s42255-024-01041-8. Acesso em: 4 ago. 2026.
ZHANG, H. et al. Relationship between body composition, insulin resistance, and hormonal profiles in women with polycystic ovary syndrome. Frontiers in Endocrinology, v. 13, 2023. DOI: https://doi.org/10.3389/fendo.2022.1085656. Disponível em: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1085656/full. Acesso em: 4 ago. 2026.
ZHAO, R. et al. Multiomics analysis reveals molecular abnormalities in granulosa cells of women with polycystic ovary syndrome. Frontiers in Genetics, v. 12, 2021. DOI: https://doi.org/10.3389/fgene.2021.648701. Disponível em: https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.648701/full. Acesso em: 4 ago. 2026.
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