BIOTECHNOLOGY APPLIED TO AESTHETICS: EXOSOMES AND BIOMIMETIC PEPTIDES IN SKIN REJUVENATION
DOI:
https://doi.org/10.63330/armv2n5-082Keywords:
Aesthetic biotechnology, Exosomes, Biomimetic peptides, Skin rejuvenation, Cellular regenerationAbstract
Biotechnology has driven significant advances in the field of aesthetics, particularly in the development of innovative therapies aimed at skin rejuvenation. In this context, exosomes and biomimetic peptides stand out as promising approaches capable of directly targeting the cellular mechanisms responsible for skin aging. Exosomes are nanosized extracellular vesicles secreted by various cell types, playing a crucial role in intercellular communication. They carry proteins, lipids, messenger RNA, and microRNAs, enabling the modulation of biological processes such as cell proliferation, inflammation, and tissue regeneration. In aesthetics, exosomes—especially those derived from stem cells—have been widely explored due to their ability to stimulate collagen and elastin production, promote tissue repair, and improve skin texture and firmness, thereby reducing wrinkles and visible signs of aging. Biomimetic peptides, on the other hand, are short chains of amino acids designed to mimic natural biological functions. They act as cellular signaling molecules, stimulating collagen synthesis, inhibiting extracellular matrix degradation, and promoting effects similar to those of endogenous compounds. Some peptides exhibit “botox-like” activity, reducing muscle contraction and softening expression lines, while others demonstrate regenerative and antioxidant properties. The combined use of exosomes and biomimetic peptides enhances therapeutic outcomes, as both act synergistically in skin regeneration and revitalization. This synergy contributes to more effective and longer-lasting results, often through less invasive approaches compared to traditional procedures. Therefore, the application of exosomes and biomimetic peptides represents a growing trend in aesthetic biotechnology, offering safe and effective alternatives for skin rejuvenation. However, further clinical studies and standardized protocols are still required to ensure long-term efficacy and safety.
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References
ATALA, A.; et al. Regenerative medicine and tissue engineering strategies in dermatology. New York: Academic Press, 2019.
BARRIENTOS, S. et al. Growth factors and cytokines in wound healing. Wound Repair and Regeneration, v. 16, n. 5, p. 585-601, 2008.
BLANES-MIRA, C. et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science, v. 24, n. 5, p. 303-310, 2022.
EL ANDALOUSSI, S. et al. Extracellular vesicles: biology and emerging therapeutic applications. Nature Reviews Drug Discovery, v. 12, p. 347-357, 2023.
ELIAS, P. M.; WILLIAMS, M. L. Cutaneous biology and barrier function in aging skin. Dermatologic Clinics, v. 38, n. 3, p. 221-233, 2020.
FERREIRA, L. M.; COSTA, R. A. Biotecnologia aplicada à estética regenerativa: exossomos e peptídeos biomiméticos. Revista Brasileira de Estética Avançada, v. 5, n. 2, p. 45-60, 2023.
FISHER, G. J. et al. Mechanisms of photoaging and chronological skin aging. Archives of Dermatological Research, v. 311, n. 10, p. 703-716, 2019.
FRANCESCHI, C. et al. Inflammaging and anti-inflammaging: a systemic perspective. Annual Review of Pathology, v. 13, p. 235-262, 2018.
GILCHREST, B. A. Photoaging and skin cancer: lessons from the UV radiation. New England Journal of Medicine, v. 368, p. 1231-1239, 2023.
GOROUHI, F.; MAIBACH, H. I. Role of topical peptides in skin aging. Clinical Dermatology, v. 27, n. 5, p. 465-470, 2019.
KALLURI, R.; LEBLEU, V. S. The biology, function, and biomedical applications of exosomes. Science, v. 367, n. 6478, 2020.
KAMEL, M.; ALI, A.; EL-RAHMAN, S. Skin aging mechanisms and therapeutic approaches. Dermatology Research and Practice, v. 2021, p. 1-10, 2021.
KIM, H. S. et al. Clinical applications of regenerative aesthetics. Aesthetic Surgery Journal, v. 41, n. 9, p. 1012-1025, 2021.
KRUTMANN, J. et al. Pollution and skin aging. Journal of Investigative Dermatology, v. 137, n. 1, p. 1-5, 2017.
LINTNER, K.; PERSICHETTI, L. A. Peptides in cosmetic science. International Journal of Cosmetic Science, v. 22, n. 2, p. 73-82, 2020.
MORA-HUERTAS, C. E.; FESSI, H.; ELAISSARI, A. Polymer-based nanocapsules for drug delivery. International Journal of Pharmaceutics, v. 385, p. 113-142, 2020.
PEGTEL, D. M.; GOULD, S. J. Exosomes. Annual Review of Biochemistry, v. 88, p. 487-514, 2019.
PITTENGER, M. F. et al. Mesenchymal stem cell perspective. Stem Cells, v. 37, n. 6, p. 753-761, 2019.
QUAN, T.; FISHER, G. J. Role of matrix degradation in skin aging. Journal of Investigative Dermatology, v. 135, p. 1743-1749, 2015.
RANADE, S. S. et al. Standardization challenges in exosome therapy. Theranostics, v. 11, n. 5, p. 2201-2215, 2021.
RANI, S. et al. Extracellular vesicles in disease and therapy. Journal of Extracellular Vesicles, v. 4, 2015.
SALMINEN, A. et al. NF-kB signaling in aging and disease. Ageing Research Reviews, v. 45, p. 35-49, 2018.
SCHAGEN, S. K. Topical anti-aging peptides. Cosmetics, v. 4, n. 2, p. 16-28, 2017.
SBD – SOCIEDADE BRASILEIRA DE DERMATOLOGIA. Envelhecimento cutâneo e estresse oxidativo. Rio de Janeiro, 2023.
ZHANG, H.; DUAN, Y.; WANG, X. Skin aging mechanisms and interventions. International Journal of Molecular Sciences, v. 23, n. 9, 2022.
ZHANG, Y. et al. Exosomes in skin regeneration and aging. Frontiers in Cell and Developmental Biology, v. 11, 2023.
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