DRUG-INDUCED NEPHROTOXICITY: STRATEGIES FOR CLINICAL PRACTICE

Abstract

Drug-induced nephrotoxicity is a significant clinical complication associated with increased morbidity, mortality, and costs. This article presents essential strategies to mitigate the risk of drug-induced kidney injury. Identifying and monitoring high-risk patients is crucial, including those with pre-existing renal dysfunction, the elderly, patients with volume depletion, and those on nephrotoxic polypharmacy. Serial assessment of renal function is imperative. Dosage adjustment based on renal function and selection of less nephrotoxic therapeutic alternatives are key strategies. Adequate hydration, especially with amphotericin B, attenuates the tubular concentration of the drug. Avoiding concomitant administration of multiple nephrotoxic drugs is essential, requiring careful review of pharmacotherapy. Future research focuses on biomarkers for early detection and the development of less nephrotoxic drugs. Careful implementation of these strategies is critical to patient safety. It is evident that drug-induced nephrotoxicity requires a multifaceted approach, with prevention, early detection, and appropriate management to ensure patient safety and well-being.